Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression*
Identifieur interne : 001C97 ( Main/Exploration ); précédent : 001C96; suivant : 001C98Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression*
Auteurs : Ben A. Bailey-Elkin ; Robert C. M. Knaap ; Garrett G. Johnson ; Tim J. Dalebout ; Dennis K. Ninaber ; Puck B. Van Kasteren ; Peter J. Bredenbeek ; Eric J. Snijder ; Marjolein Kikkert ; Brian L. MarkSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.
Descripteurs français
- KwdFr :
- Cellules HEK293, Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie), Cristallographie aux rayons X, Domaine catalytique, Humains, Immunité innée, Modèles moléculaires, Motifs d'acides aminés, Mutagenèse, Mutation, Papaïne (), Papaïne (génétique), Papaïne (métabolisme), Tolérance immunitaire, Ubiquitine (), Ubiquitine (métabolisme), Ubiquitinylation.
- MESH :
- enzymologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- génétique : Papaïne.
- métabolisme : Papaïne, Ubiquitine.
- Cellules HEK293, Cristallographie aux rayons X, Domaine catalytique, Humains, Immunité innée, Modèles moléculaires, Motifs d'acides aminés, Mutagenèse, Mutation, Papaïne, Tolérance immunitaire, Ubiquitine, Ubiquitinylation.
English descriptors
- KwdEn :
- Amino Acid Motifs, Catalytic Domain, Crystallography, X-Ray, HEK293 Cells, Humans, Immune Tolerance, Immunity, Innate, Middle East Respiratory Syndrome Coronavirus (enzymology), Models, Molecular, Mutagenesis, Mutation, Papain (chemistry), Papain (genetics), Papain (metabolism), Ubiquitin (chemistry), Ubiquitin (metabolism), Ubiquitination.
- MESH :
- chemical , chemistry : Papain, Ubiquitin.
- enzymology : Middle East Respiratory Syndrome Coronavirus.
- chemical , genetics : Papain.
- chemical , metabolism : Papain, Ubiquitin.
- Amino Acid Motifs, Catalytic Domain, Crystallography, X-Ray, HEK293 Cells, Humans, Immune Tolerance, Immunity, Innate, Models, Molecular, Mutagenesis, Mutation, Ubiquitination.
Abstract
Url:
DOI: 10.1074/jbc.M114.609644
PubMed: 25320088
PubMed Central: 4263872
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Crystal Structure of the Middle East Respiratory Syndrome Coronavirus
(MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted
Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune
Suppression<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Bailey Elkin, Ben A" sort="Bailey Elkin, Ben A" uniqKey="Bailey Elkin B" first="Ben A." last="Bailey-Elkin">Ben A. Bailey-Elkin</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Knaap, Robert C M" sort="Knaap, Robert C M" uniqKey="Knaap R" first="Robert C. M." last="Knaap">Robert C. M. Knaap</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Johnson, Garrett G" sort="Johnson, Garrett G" uniqKey="Johnson G" first="Garrett G." last="Johnson">Garrett G. Johnson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dalebout, Tim J" sort="Dalebout, Tim J" uniqKey="Dalebout T" first="Tim J." last="Dalebout">Tim J. Dalebout</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Ninaber, Dennis K" sort="Ninaber, Dennis K" uniqKey="Ninaber D" first="Dennis K." last="Ninaber">Dennis K. Ninaber</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Van Kasteren, Puck B" sort="Van Kasteren, Puck B" uniqKey="Van Kasteren P" first="Puck B." last="Van Kasteren">Puck B. Van Kasteren</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Bredenbeek, Peter J" sort="Bredenbeek, Peter J" uniqKey="Bredenbeek P" first="Peter J." last="Bredenbeek">Peter J. Bredenbeek</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J." last="Snijder">Eric J. Snijder</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kikkert, Marjolein" sort="Kikkert, Marjolein" uniqKey="Kikkert M" first="Marjolein" last="Kikkert">Marjolein Kikkert</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Mark, Brian L" sort="Mark, Brian L" uniqKey="Mark B" first="Brian L." last="Mark">Brian L. Mark</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25320088</idno><idno type="pmc">4263872</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263872</idno><idno type="RBID">PMC:4263872</idno><idno type="doi">10.1074/jbc.M114.609644</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000D86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D86</idno><idno type="wicri:Area/Pmc/Curation">000D86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D86</idno><idno type="wicri:Area/Pmc/Checkpoint">001111</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001111</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:25320088</idno><idno type="wicri:Area/PubMed/Corpus">001815</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001815</idno><idno type="wicri:Area/PubMed/Curation">001815</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001815</idno><idno type="wicri:Area/PubMed/Checkpoint">001951</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001951</idno><idno type="wicri:Area/Ncbi/Merge">000F32</idno><idno type="wicri:Area/Ncbi/Curation">000F32</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F32</idno><idno type="wicri:doubleKey">0021-9258:2014:Bailey Elkin B:crystal:structure:of</idno><idno type="wicri:Area/Main/Merge">001D11</idno><idno type="wicri:Area/Main/Curation">001C97</idno><idno type="wicri:Area/Main/Exploration">001C97</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Crystal Structure of the Middle East Respiratory Syndrome Coronavirus
(MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted
Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune
Suppression<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Bailey Elkin, Ben A" sort="Bailey Elkin, Ben A" uniqKey="Bailey Elkin B" first="Ben A." last="Bailey-Elkin">Ben A. Bailey-Elkin</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Knaap, Robert C M" sort="Knaap, Robert C M" uniqKey="Knaap R" first="Robert C. M." last="Knaap">Robert C. M. Knaap</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Johnson, Garrett G" sort="Johnson, Garrett G" uniqKey="Johnson G" first="Garrett G." last="Johnson">Garrett G. Johnson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dalebout, Tim J" sort="Dalebout, Tim J" uniqKey="Dalebout T" first="Tim J." last="Dalebout">Tim J. Dalebout</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Ninaber, Dennis K" sort="Ninaber, Dennis K" uniqKey="Ninaber D" first="Dennis K." last="Ninaber">Dennis K. Ninaber</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Van Kasteren, Puck B" sort="Van Kasteren, Puck B" uniqKey="Van Kasteren P" first="Puck B." last="Van Kasteren">Puck B. Van Kasteren</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Bredenbeek, Peter J" sort="Bredenbeek, Peter J" uniqKey="Bredenbeek P" first="Peter J." last="Bredenbeek">Peter J. Bredenbeek</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J." last="Snijder">Eric J. Snijder</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kikkert, Marjolein" sort="Kikkert, Marjolein" uniqKey="Kikkert M" first="Marjolein" last="Kikkert">Marjolein Kikkert</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Mark, Brian L" sort="Mark, Brian L" uniqKey="Mark B" first="Brian L." last="Mark">Brian L. Mark</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Motifs</term><term>Catalytic Domain</term><term>Crystallography, X-Ray</term><term>HEK293 Cells</term><term>Humans</term><term>Immune Tolerance</term><term>Immunity, Innate</term><term>Middle East Respiratory Syndrome Coronavirus (enzymology)</term><term>Models, Molecular</term><term>Mutagenesis</term><term>Mutation</term><term>Papain (chemistry)</term><term>Papain (genetics)</term><term>Papain (metabolism)</term><term>Ubiquitin (chemistry)</term><term>Ubiquitin (metabolism)</term><term>Ubiquitination</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules HEK293</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie)</term><term>Cristallographie aux rayons X</term><term>Domaine catalytique</term><term>Humains</term><term>Immunité innée</term><term>Modèles moléculaires</term><term>Motifs d'acides aminés</term><term>Mutagenèse</term><term>Mutation</term><term>Papaïne ()</term><term>Papaïne (génétique)</term><term>Papaïne (métabolisme)</term><term>Tolérance immunitaire</term><term>Ubiquitine ()</term><term>Ubiquitine (métabolisme)</term><term>Ubiquitinylation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Papain</term><term>Ubiquitin</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Papain</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Papaïne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Papain</term><term>Ubiquitin</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Papaïne</term><term>Ubiquitine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Motifs</term><term>Catalytic Domain</term><term>Crystallography, X-Ray</term><term>HEK293 Cells</term><term>Humans</term><term>Immune Tolerance</term><term>Immunity, Innate</term><term>Models, Molecular</term><term>Mutagenesis</term><term>Mutation</term><term>Ubiquitination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HEK293</term><term>Cristallographie aux rayons X</term><term>Domaine catalytique</term><term>Humains</term><term>Immunité innée</term><term>Modèles moléculaires</term><term>Motifs d'acides aminés</term><term>Mutagenèse</term><term>Mutation</term><term>Papaïne</term><term>Tolérance immunitaire</term><term>Ubiquitine</term><term>Ubiquitinylation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> MERS-CoV papain-like protease (PL<sup>pro</sup>)
processes viral polyproteins and has deubiquitinating activity.</p><p><bold>Results:</bold> A crystal structure of MERS-CoV PL<sup>pro</sup> bound to
ubiquitin guided mutagenesis to disrupt PL<sup>pro</sup> deubiquitinating
activity without affecting polyprotein cleavage.</p><p><bold>Conclusion:</bold> The deubiquitinating activity of MERS-CoV
PL<sup>pro</sup> suppresses the induction of interferon-β
expression.</p><p><bold>Significance:</bold> Our strategy to selectively disable PL<sup>pro</sup>deubiquitinating activity enables the study of its specific functions in
infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A. M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T. M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. Osterhaus</name></author><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R. A. M. Fouchier</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, E I" uniqKey="Azhar E">E. I. Azhar</name></author><author><name sortKey="El Kafrawy, S A" uniqKey="El Kafrawy S">S. A. El-Kafrawy</name></author><author><name sortKey="Farraj, S A" uniqKey="Farraj S">S. A. Farraj</name></author><author><name sortKey="Hassan, A M" uniqKey="Hassan A">A. M. 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Bredenbeek</name><name sortKey="Dalebout, Tim J" sort="Dalebout, Tim J" uniqKey="Dalebout T" first="Tim J." last="Dalebout">Tim J. Dalebout</name><name sortKey="Johnson, Garrett G" sort="Johnson, Garrett G" uniqKey="Johnson G" first="Garrett G." last="Johnson">Garrett G. Johnson</name><name sortKey="Kikkert, Marjolein" sort="Kikkert, Marjolein" uniqKey="Kikkert M" first="Marjolein" last="Kikkert">Marjolein Kikkert</name><name sortKey="Knaap, Robert C M" sort="Knaap, Robert C M" uniqKey="Knaap R" first="Robert C. M." last="Knaap">Robert C. M. Knaap</name><name sortKey="Mark, Brian L" sort="Mark, Brian L" uniqKey="Mark B" first="Brian L." last="Mark">Brian L. Mark</name><name sortKey="Ninaber, Dennis K" sort="Ninaber, Dennis K" uniqKey="Ninaber D" first="Dennis K." last="Ninaber">Dennis K. Ninaber</name><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J." last="Snijder">Eric J. Snijder</name><name sortKey="Van Kasteren, Puck B" sort="Van Kasteren, Puck B" uniqKey="Van Kasteren P" first="Puck B." last="Van Kasteren">Puck B. Van Kasteren</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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